Multiple witnesses tell us a movie shoot -- involving Ice Cube and Dr. Dre -- was going down when Suge pulled up in his car. We're told security told Suge to leave and that's when trouble began.
A fight broke out between Suge and 2 men. Suge got back into his car, took the wheel and threw the vehicle in reverse ... and ran over a man who suffered fatal injuries.
It's unclear at this point if the victim was connected to the movie. A source close to Cube tells us production had wrapped when the fight went down ... and he and Dre were not on set.
Sources connected with Suge tell TMZ ... the 2 men who fought Suge were the instigators. Our sources say Suge was scared because he's in frail health -- in addition to being shot 6 times last summer, he recently almost died from a blood clot.
The victim is Terry Carter, who we're told is a friend of Suge's who arrived with him at the scene. Our sources say Carter was in the process of walking to the passenger door of Suge's vehicle, but happened to be in the rear when Suge gunned it.
Two other men were also hit ... including Cle "Bone" Sloane -- who's appeared in "Training Day" and "End of Watch" -- and suffered non-life threatening injuries. Both men are in the hospital.Suge has been placed under arrest and is being held on $2 million bail.
Sgt. Diane Hecht of the Los Angeles County Sheriff's information office said Knight was arrested at about 3 a.m. and is being held on $2 million bail.
Hecht says Knight is being held at the West Hollywood sheriff's station.
Knight turned himself in to authorities early Friday after his attorney said the rap mogul ran over and killed a friend and injured another man.
The Los Angeles Times reported that Knight and his attorney James Blatt arrived at the Los Angeles County Sheriff's Department West Hollywood station early Friday.
"We are confident that once the investigation is completed, he will be totally exonerated," Blatt told the Associated Press by phone late Thursday.
MyFoxLA first reported that Knight was driving a red pickup truck that struck two men shortly before 3 p.m. local time in Compton, Calif., outside Los Angeles. The injured man was taken to a hospital and his condition was not immediately known. No identifying information about either man was available.
The Times reported that the tragedy stemmed from an altercation that occurred on the set of a forthcoming film titled "Straight Outta Compton," a biopic about the rap group NWA.
A rep for the Sheriff's Department confirmed to FOX411 the trouble began on a film set.
"There was an initial altercation at [a] film set but [the incident] did not occur at the film set," the rep explained.
Los Angeles County Sheriff's Department Capt. John Corina said that the two men Knight argued with went to a nearby restaurant about 20 minutes after the confrontation.
Corina alleged Knight followed the men there in a red truck and ran them over in the parking lot. Witnesses told the paper the truck hit the men, then backed over them before fleeing the scene. The incident is being investigated as a homicide.
"The people we talked to say it looked like it was an intentional act," Corina told reporters.
However, attorney Blatt claimed it was an accident.
"He was in the process of being physically assaulted by two men and in an effort to escape he unfortunately hit two (other) individuals," the lawyer said. "He was in his car trying to escape."
The empty truck was found late Thursday night in a West Los Angeles parking lot, Corina said.