Sixteen firefighters who were among 606 who trained or worked at the Fiskville training centre between 1971 and 1999 have died from cancer.
Premier Daniel Andrews revealed details of a cancer cluster at the site, saying victims and their families are entitled to answers and better treatment than they received in the past.
"The evidence is becoming clearer and clearer each day that people have become sick because of this place, people have died because of this place," he told reporters on Wednesday.
"There is a statistical over-representation, there is a cancer cluster."
Mr Andrews said the risk to those at the site now was low because of remediation works.
"When Brian Potter died the former government still clung to the fiction that Fiskville was safe and they refused to recognise his cancers as work-related or to support him and his family," union spokesman Mick Tisbury said.
He said those who sent firefighters to the site had no choice now but to resign.
Cancer cluster figures
* 606 firefighters traced between 1971 and 1999
* 95 declared high risk, 256 medium risk
* 69 have cancer, including 25 high risk and 38 medium risk
* 16 have died, including 6 high risk and 9 medium risk
* Higher risks of brain, testicular, melanoma and nervous system cancers


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