The raid, in which two others were also injured, took place in the Khogyani district of Nangarhar on Tuesday, Afghan police said.
The US carries out targeted killings through drone strikes in several Muslim countries such as Yemen, Pakistan, Afghanistan and Somalia.
Washington claims the targets of the drone attacks are militants, but local officials and witnesses maintain that civilians have been the main victims of the attacks over the past few years.
People and officials in Afghanistan have protested over the civilian casualties on numerous occasions, but the US drone attacks continue unabated.
The United Nations and several human rights organizations have identified the US as the world’s number one user of “targeted killings,” largely due to its drone attacks in Pakistan and Afghanistan.